Compile Data Set for Download or QSAR
Report error Found 335 of affinity data for UniProtKB/TrEMBL: P08049
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50367820(CHEMBL1907967)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50087104(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Affinity DataKi:  0.940nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035236(3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propi...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035251(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-succi...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051784((2S,5R)-5-(2-Hydroxy-phenyl)-1-[2-((S)-2-mercapto-...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051803((2S,5R)-1-{2-[3-(4-Chloro-phenyl)-2-mercapto-propi...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115846((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  1.30nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50050158(1-[(S)-2-((R)-2-Mercapto-3-phenyl-propionylamino)-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity was tested against neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50087088((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50002022(CHEMBL16779 | (2-Benzyl-3-hydroxycarbamoyl-propion...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]D-Ala2-Leu-enkephalin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50002022(CHEMBL16779 | (2-Benzyl-3-hydroxycarbamoyl-propion...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50050127((S)-3-(4-Hydroxy-phenyl)-2-[(2S,3R)-2-((S)-2-merca...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity was tested against neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50017742(CHEMBL316180 | disodium 2-benzyl-4-(3-carboxylatop...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Enkephalinase from rabbit using method 2 is determined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50039513((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21649((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-(4-phenylpheny...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051800(1-{2-[(S)-3-(4-Hydroxy-phenyl)-2-mercapto-propiony...)
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051785((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051791((2S,5R)-5-(3-Hydroxy-phenyl)-1-{2-[(S)-3-(4-hydrox...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50020153(CHEMBL55056 | N-(1-Benzyl-2-hydroxycarbamoyl-ethyl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50018211(CHEMBL36094 | 3-(2-Benzyl-3-hydroxycarbamoyl-propi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]D-Ala2-Leu-enkephalin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50018211(CHEMBL36094 | 3-(2-Benzyl-3-hydroxycarbamoyl-propi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]D-Ala2-Leu-enkephalin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50018216(CHEMBL290337 | 2-Benzyl-3-(2-benzyl-3-hydroxycarba...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]D-Ala2-Leu-enkephalin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50051794((2S,5R)-1-{2-[(S)-3-(4-Amino-phenyl)-2-mercapto-pr...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115842(2-(2-Indan-1-yl-3-mercapto-propionylamino)-3-(1H-i...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50115843((2S)-2-[(2R)-2-[(1R)-5-bromo-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21639((2S)-2-[2-(2,3-dihydro-1H-inden-1-yl)-3-sulfanylpr...)
Affinity DataKi:  1.80nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50: 1.90nMAssay Description:Tested for inhibition against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.90nMAssay Description:Tested for binding affinity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50087113((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035239(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50039541((S)-2-((S)-2-Mercaptomethyl-3-naphthalen-1-yl-prop...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50017736(CHEMBL86291 | 2-Benzyl-4-(3-carboxy-propionylamino...)
Affinity DataIC50: 2nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50039499((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035236(3-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-propi...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035249(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21654((2S)-2-[(2S)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  2.10nM ΔG°:  -51.5kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM21644((2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
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