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Report error Found 269 of affinity data for UniProtKB/TrEMBL: P09769
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.400nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50: 0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.5nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50601440(CHEMBL5176837)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.5nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  0.5nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.658nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against Fgr kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 2.30nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  2.40nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of Fgr protein kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of recombinant FGR (unknown origin) preincubated for 1 hr in presence of ATP by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 3.70nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM473172(US10844038, Example 46 B. | (3R,4R)-3-((4-amino-3-...)
Affinity DataIC50: 5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM473171(US10844038, Example 43 B. | (3R,4S)-3-((4-amino-3-...)
Affinity DataIC50: 5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM473174(US10844038, Example 43 A. | (3S,4R)-3-((4-amino-3-...)
Affinity DataIC50: 5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50571039(CHEMBL4877846)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  6.30nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  7nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 8nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50647988(CHEMBL5598020)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of Fgr (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184785(CHEMBL3823620 | US10294227, Code 553)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184782(CHEMBL3824228 | US10294227, Code 543)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184781(CHEMBL3823543 | US10294227, Code 533)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM387836(tert-butyl N-[4-[4-amino-1-[2-(4-methoxy-1-piperid...)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM387854(US10294227, Code 584)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184786(CHEMBL3824116 | US10294227, Code 565)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM387846(US10294227, Code 503)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184777(CHEMBL3823104 | US10294227, Code 519)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184776(CHEMBL3824233 | US10294227, Code 518)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataIC50: 10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM230107(US9334290, 32 | US10106559, Example 33 | US9850258...)
Affinity DataIC50: 15nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKi:  15nMAssay Description:Inhibition of human FGR assessed as inhibition constant in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  17nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  17nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  17nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 23nMAssay Description:Inhibition of human FGR in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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