Compile Data Set for Download or QSAR
Report error Found 75 for UniProtKB: P0AFI2
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi:  7nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi:  11nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi:  12nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi:  14nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi:  23nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi:  35nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737448(US20250136618, Compound 4)
Affinity DataIC50: 44nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737446(US20250136618, Compound 2)
Affinity DataIC50: 45nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi:  46nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM595423(US11590142, Compound 13 | US20250136618, Compound ...)
Affinity DataIC50: 50nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737447(US20250136618, Compound 3)
Affinity DataIC50: 50nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi:  58nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737454(US20250136618, Compound 10)
Affinity DataIC50: 78nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi:  78nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737453(US20250136618, Compound 9)
Affinity DataIC50: 91nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518915(CHEMBL4583368)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518948(CHEMBL4574863)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518940(CHEMBL4541988)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  110nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737449(US20250136618, Compound 5)
Affinity DataIC50: 110nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM737450(US20250136618, Compound 6)
Affinity DataIC50: 130nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  150nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518924(CHEMBL4533152)
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24612(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...)
Affinity DataKi:  390nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518911(CHEMBL4530328)
Affinity DataIC50: 400nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24613(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24602(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518928(CHEMBL4544202)
Affinity DataIC50: 700nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518918(CHEMBL4569403)
Affinity DataIC50: 900nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518922(CHEMBL4441397)
Affinity DataIC50: 900nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24600(3-ethyl-1-[5-(pyrimidin-5-yl)-1H-1,3-benzodiazol-2...)
Affinity DataKi:  1.10E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518926(CHEMBL4536608)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518933(CHEMBL4567626)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24610(1-[5,7-bis(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-...)
Affinity DataKi:  1.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518941(CHEMBL4465361)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518932(CHEMBL4467826)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  1.40E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518938(CHEMBL4445613)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518910(CHEMBL4554663)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518944(CHEMBL4537564)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50393503(CHEMBL2158050)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Escherichia coli DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 60 mins by eth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518917(CHEMBL4453182)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24598(3-ethyl-1-[5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-y...)
Affinity DataKi:  2.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518943(CHEMBL4435611)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518951(CHEMBL4570423)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518925(CHEMBL4438807)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518927(CHEMBL4549719)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518920(CHEMBL4465692)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM50518936(CHEMBL4538428)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandPNGBDBM24605(3-ethyl-1-[6-(piperidin-1-yl)-5-(pyridin-3-yl)-1H-...)
Affinity DataKi:  3.30E+3nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
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