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Report error Found 37 of affinity data for UniProtKB/TrEMBL: P0C6X5
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.770nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataKi:  0.800nMAssay Description:Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021205298

TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728213(US20250092029, Compound AP-8-001)
Affinity DataIC50: 11nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728214(US20250092029, Compound GC-376)
Affinity DataIC50: 18nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 107nMAssay Description:The fluorescence resonance energy transfer method reported in the literature is adopted (J in et al 0.2020. Structure of Mprofrom SARS-CoV-2 and disc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataEC50:  120nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 120nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728212(US20250092029, Compound AP-8-013)
Affinity DataIC50: 230nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataEC50:  350nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 360nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  440nMAssay Description:CPE assay was carried out in Huh-7 cells in the presence or absence of P-glycoprotein inhibitor CP-100356.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataIC50: 450nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  480nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataEC50:  540nMAssay Description:CPE assay was carried out in Huh-7 cells in the presence or absence of P-glycoprotein inhibitor CP-100356.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728216(US20250092029, Compound AP-8-012)
Affinity DataIC50: 580nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728215(US20250092029, Compound AP-8-011)
Affinity DataIC50: 620nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataEC50:  770nMAssay Description:CPE assay was carried out in Huh-7 cells in the presence or absence of P-glycoprotein inhibitor CP-100356.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataEC50:  1.27E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  1.31E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420980(US9975885, Compound 37)
Affinity DataIC50: 3.00E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataEC50:  3.68E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420978(US9975885, Compound 33)
Affinity DataIC50: 3.70E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420974(US9975885, Compound 30)
Affinity DataIC50: 4.20E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420996(US9975885, Compound 77)
Affinity DataIC50: 5.10E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420993(US9975885, Compound 47)
Affinity DataIC50: 6.30E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420973(US9975885, Compound 29)
Affinity DataIC50: 8.10E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420991(US9975885, Compound 44)
Affinity DataIC50: 8.20E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420981(US9975885, Compound 64)
Affinity DataIC50: 8.70E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420975(US9975885, Compound 31)
Affinity DataIC50: 1.18E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420990(US9975885, Compound 43)
Affinity DataIC50: 1.35E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420977(US9975885, Compound 32)
Affinity DataIC50: 1.48E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420979(US9975885, Compound 34)
Affinity DataIC50: 1.56E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420992(US9975885, Compound 46)
Affinity DataIC50: 1.68E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420983(med.21724, Compound 125 | US9975885, Compound 3P)
Affinity DataIC50: 2.23E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM749380(US20250188102, Compound SHEN211)
Affinity DataIC50: 2.60E+4nMAssay Description:The fluorescence resonance energy transfer method reported in the literature is adopted (J in et al 0.2020. Structure of Mprofrom SARS-CoV-2 and disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM420994(US9975885, Compound 48)
Affinity DataIC50: 2.64E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer

LigandPNGBDBM639154(US20230391736, Example S-217622 | US20250025459, C...)
Affinity DataIC50: 2.78E+4nMAssay Description:The fluorescence resonance energy transfer method reported in the literature is adopted (J in et al 0.2020. Structure of Mprofrom SARS-CoV-2 and disc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)