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Report error Found 1749 of affinity data for UniProtKB/TrEMBL: P13569
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  0.200nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50566263(CHEMBL4776653)
Affinity DataEC50: <0.310nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301470(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...)
Affinity DataEC50:  0.400nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595765(CHEMBL5178232)
Affinity DataEC50:  0.400nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301443(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...)
Affinity DataEC50:  0.410nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(US10131670, Example 13 | 4-amino-7-{1-[1-(2-fluoro...)
Affinity DataEC50:  0.420nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  0.420nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50516910(CHEMBL4558190)
Affinity DataEC50:  0.5nMAssay Description:Corrector activity at CFTR F508del mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595762(CHEMBL5193680)
Affinity DataEC50:  0.510nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  0.560nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  0.560nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301442(4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...)
Affinity DataEC50:  0.570nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(US10131670, Example 13 | 4-amino-7-{1-[1-(2-fluoro...)
Affinity DataEC50:  0.620nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301438(4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...)
Affinity DataEC50:  0.660nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595764(CHEMBL5178488)
Affinity DataEC50:  0.660nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595761(CHEMBL5202275)
Affinity DataEC50:  0.800nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595763(CHEMBL5186971)
Affinity DataEC50:  0.840nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301442(4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...)
Affinity DataEC50:  0.860nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50595766(CHEMBL5171054)
Affinity DataEC50:  0.900nMAssay Description:Modulation of homozygous F508del/F508del CFTR mutant in HBE cells incubated for 18 to 24 hrs by trans-epithelial current clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301443(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...)
Affinity DataEC50:  1.05nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50566262(CHEMBL4799994)
Affinity DataEC50:  1.10nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  1.53nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301435(4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...)
Affinity DataEC50:  1.67nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301449(US10131670, Example 82 | 7-{1-[1-(2-fluorophenyl)-...)
Affinity DataEC50:  1.88nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50035582(CHEMBL3357142)
Affinity DataEC50:  2nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301431(BDBM301432 | US10131670, Example 14 | 4-amino-7-{1...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301449(US10131670, Example 82 | 7-{1-[1-(2-fluorophenyl)-...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301451(US10131670, Example 60 | 7-{1-[1-(2,4-difluorophen...)
Affinity DataEC50:  2nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50032694(CHEMBL3354672)
Affinity DataEC50:  2.10nMAssay Description:Inhibition of CFTR F508 deletion mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301421(4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...)
Affinity DataEC50:  2.13nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50566258(CHEMBL4787310)
Affinity DataEC50:  2.80nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50035581(CHEMBL3357141)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50035583(CHEMBL3357143)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301433(BDBM301434 | 4-amino-7-{1-[1-(2,4-difluorophenyl)-...)
Affinity DataEC50:  3nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301421(4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...)
Affinity DataEC50:  3.02nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301435(4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...)
Affinity DataEC50:  3.10nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301438(4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...)
Affinity DataEC50:  3.13nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301451(US10131670, Example 60 | 7-{1-[1-(2,4-difluorophen...)
Affinity DataEC50:  3.36nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50566256(CHEMBL4798183)
Affinity DataEC50:  3.40nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50165000((S)-2-(3-Isopropoxy-4-methoxy-benzoyl)-1,2,3,4-tet...)
Affinity DataEC50:  3.5nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301471(4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...)
Affinity DataEC50:  3.87nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(US10131670, Example 13 | 4-amino-7-{1-[1-(2-fluoro...)
Affinity DataEC50:  4nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM50434312(CHEMBL2386374)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human CFTR chloride conductance expressed in forskolin-stimulated rat FRT cells by short-circuit current analysis in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301444(4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...)
Affinity DataEC50:  4nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301427(4-amino-7-{1-[1-(propan-2-yl)-1H-pyrazol-4-yl]prop...)
Affinity DataEC50:  4.17nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301444(4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...)
Affinity DataEC50:  4.65nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  4.76nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301449(US10131670, Example 82 | 7-{1-[1-(2-fluorophenyl)-...)
Affinity DataEC50:  4.93nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

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