Compile Data Set for Download or QSAR
Report error Found 108 for UniProtKB: P14646
LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50110039(1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50450772(CHEMBL322092)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
LigandPNGBDBM50450771(CHEMBL326655)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
LigandPNGBDBM50450770(CHEMBL320307)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50218545(Nitraquazone)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50: 15nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataKi:  16.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50: 25nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM86218(NSC_0 | CAS_0 | Desmethylpiclamilas)
Affinity DataKi:  34.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072195(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Affinity DataIC50: 43nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085138(4-[8-(3-Chloro-phenyl)-[1,7]naphthyridin-6-yl]-ben...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085135(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Affinity DataIC50: 49nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072194(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Affinity DataIC50: 50nMAssay Description:Inhibition of [3H]-rolipram binding to membrane-bound PDE4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50451480(CHEMBL2093042)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50072195(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Affinity DataIC50: 70nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072211(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 80nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085146(8-(3-Nitro-phenyl)-6-pyridin-3-yl-[1,7]naphthyridi...)
Affinity DataIC50: 81nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085139(4-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-benz...)
Affinity DataIC50: 85nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072199(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Affinity DataIC50: 110nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085136(8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine | C...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM14773(Ariflo | 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyph...)
Affinity DataKi:  118nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50072200(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 145nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085140(6-Allyl-8-(3-nitro-phenyl)-[1,7]naphthyridine | CH...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50110030(1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataKi:  189nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072209(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 200nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072200(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 200nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14773(Ariflo | 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyph...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50072199(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Affinity DataIC50: 210nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50366802(CHEMBL1788264)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50072194(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Affinity DataIC50: 300nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085141(Trifluoro-methanesulfonic acid 8-(3-nitro-phenyl)-...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM86222(CAS_62824 | NSC_62824 | ICI 63, 197)
Affinity DataKi:  313nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072209(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 340nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085147(8-(3-Nitro-phenyl)-6-o-tolyl-[1,7]naphthyridine | ...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085143(Trifluoro-methanesulfonic acid 8-(3-cyano-phenyl)-...)
Affinity DataIC50: 420nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072204(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethylsu...)
Affinity DataIC50: 440nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085145(Trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)...)
Affinity DataIC50: 460nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
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