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TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50206389(CHEMBL3939307)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50236362(N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618815(CHEMBL5407330)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd:  0.740nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618818(CHEMBL5410108)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618817(CHEMBL5412144)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618809(CHEMBL5403470)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618814(CHEMBL5394759)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618825(CHEMBL5421802)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50375642(KRN-633 | CHEMBL406381)
Affinity DataIC50: 1nMAssay Description:Inhibition of human VEGFR1 in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50240780(CHEMBL4062877)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant VEGFR-1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50185178(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618808(CHEMBL5393865)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168397(2,4-difluoro-5-(5-isopropyl-6-(5-methyloxazol-2-yl...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618820(CHEMBL5438830)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50381716(US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...)
Affinity DataIC50: 1.25nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618802(CHEMBL5411585)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50: 1.45nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to FLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168410(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  1.80nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  1.80nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  1.80nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50: 1.90nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM110647(US8614234, 115 | US9725433, 115)
Affinity DataIC50: 2nMAssay Description:The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4630(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50026679(CHEMBL3335371)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50329885(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT1 by Hot Spot filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50210272(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50185181(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50137208(1-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Vascular endothelial growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKi:  2nMAssay Description:Binding affinity to VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM110647(US8614234, 115 | US9725433, 115)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2014
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM121388(US8722890, 3)
Affinity DataIC50: 2.04nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50618829(CHEMBL5421149)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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