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TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM86692(K117)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM86693(K376)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM86691(K604)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284379((6-{2-[(E)-Phenyl-pyridin-2-yl-methoxyimino]-propy...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284383({5-[2-(N'-Phenyl-N'-pyridin-3-yl-hydrazinocarbonyl...)
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM7882(CHEMBL540 | 1H-imidazole | imidazole | Imidazole (...)
Affinity DataIC50: 6.70E+5nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284385({6-[4-(Phenyl-pyridin-3-yl-methyl)-pyrazol-1-ylmet...)
Affinity DataIC50: 3.20E+5nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284380((6-{2-[(E)-Phenyl-pyridin-4-yl-methoxyimino]-propy...)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50014915(CHEMBL351115 | 4-(2-Chloro-3-trifluoromethyl-pheny...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50368035(CHEMBL1203656)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50034747(ICI-192605 | (Z)-6-[(2S,4S,5R)-2-(2-Chloro-phenyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50034747(ICI-192605 | (Z)-6-[(2S,4S,5R)-2-(2-Chloro-phenyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro Inhibition of thromboxane synthase from human blood platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053753(5-[1-Phenyl-1-pyridazin-3-yl-meth-(E)-ylideneamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053765(5-[1-Phenyl-1-pyrimidin-4-yl-meth-(E)-ylideneamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053770(5-[Pyridazin-3-yl-(3-trifluoromethyl-phenyl)-methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053781(5-[1-Phenyl-1-pyrimidin-4-yl-meth-(Z)-ylideneamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053766(5-[1-Phenyl-1-pyridazin-3-yl-meth-(Z)-ylideneamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053779(5-[1-Phenyl-1-pyrimidin-2-yl-meth-(E)-ylideneamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50053785(5-[1-Pyrimidin-4-yl-1-(3-trifluoromethyl-phenyl)-m...)
Affinity DataIC50: 1.00E+5nMAssay Description:TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]arachidonic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50313205(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human thromboxane A synthase in IL-1-beta-stimulated human RASF cells assessed as TXB2 levels after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50026541(7-Phenyl-7-pyridin-2-yl-hept-6-enoic acid | CHEMBL...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50026550(7-Phenyl-7-pyridin-4-yl-hept-6-enoic acid | CHEMBL...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50002765(BM 13177 | CHEMBL8273 | [4-(2-Benzenesulfonylamino...)
Affinity DataIC50: 9.41E+4nMAssay Description:Activity against TXA2 synthase in bovine platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284381((6-{2-[(E)-Phenyl-pyridin-3-yl-methoxyimino]-penty...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50017907(CHEMBL262055 | 3-[1-(2,2-Dimethyl-propyl)-5-pyridi...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50368038(CHEMBL1203655)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50025997(1-[2-(4-Nitro-phenoxy)-ethyl]-1H-imidazole | CHEMB...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50026009(4-(2-Imidazol-1-yl-ethoxy)-benzenesulfonamide | CH...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50426967(PF-4693627 | CHEMBL2325079)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TXAS in human 1483 cells assessed as eicosanoid level incubated for 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50043831((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50284382((5-{2-[1-Phenyl-1-pyridin-3-yl-meth-(E)-ylideneami...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against Thromboxane A2 synthase in human platelet microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of TX synthase in LPS-stimulated human whole blood assessed as inhibition of TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50337658(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of TX synthase in LPS-stimulated human whole blood assessed as inhibition of TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50337659(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of TX synthase in LPS-stimulated human whole blood assessed as inhibition of TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50337660(3-isopropyl-1-(3-(pyridin-3-ylethynyl)benzyl)-1-(3...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of TX synthase in LPS-stimulated human whole blood assessed as inhibition of TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50337661(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of TX synthase in LPS-stimulated human whole blood assessed as inhibition of TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50094191(17-Aziridin-2-ylmethyl-10,13-dimethyl-2,3,4,7,8,9,...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of thromboxane synthase P450 TXA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50302421(2-(6-(2-cyclopropylethoxy)-9-(2-hydroxy-2-methylpr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of TX synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50000328(CHEMBL157346 | 6-(1-Imidazol-1-ylmethyl-hexyl)-3,4...)
Affinity DataIC50: 2.50E+4nMAssay Description:Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50025950(6-(3-Methyl-imidazo[1,5-a]pyridin-5-yl)-hexanoic a...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibitory activity against thromboxane A2 synthetase with lysed human platelets as the enzyme source.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50014902(CHEMBL345586 | 4-(2-Difluoromethoxy-phenyl)-2-imid...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50023012(1-[2-(4-Methanesulfonyl-benzyloxy)-3-(4-methoxy-be...)
Affinity DataIC50: 2.49E+4nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50002750(CHEMBL324130 | 11-(2-Benzenesulfonylamino-ethylsul...)
Affinity DataIC50: 2.40E+4nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50017898(CHEMBL354424 | 2-Methyl-3-(1-phenyl-5-pyridin-3-yl...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50368044(CHEMBL1203649)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50025986(2-(2-Imidazol-1-yl-ethoxy)-benzamide | CHEMBL33210)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50023011(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50: 2.10E+4nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Kyowa Hakko Kogyo

Curated by PDSP Ki Database
LigandPNGBDBM50024689(8-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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