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Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM631402(US20230348421, Compound 31)
Affinity DataKi:  0.00300nMAssay Description:Displacement of [3H]ketanserin human recombinant 5-HT2A receptor by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231448(N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231459(N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570555([4-(propan-2-yloxy)phenyl]methyl N-[(7S,8aS)-octah...)
Affinity DataKi:  0.0160nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50064708((R)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Affinity DataEC50:  0.0180nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM117016(US8664258, 32 | US9987252, 32)
Affinity DataIC50: 0.0250nMAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM117016(US8664258, 32 | US9987252, 32)
Affinity DataIC50: 0.0250nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50052339(2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Affinity DataEC50:  0.0290nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50232153(CHEMBL257283 | MDL-100907 | MDL 100907 | (1-(4-flu...)
Affinity DataKi:  0.0300nM ΔG°:  -55.8kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570569(US11440884, Example 30)
Affinity DataKi:  0.0320nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50068612(2-(8-Bromo-benzo[1,2-b;4,5-b']difuran-4-yl)-1-meth...)
Affinity DataKi:  0.0400nMAssay Description:Binding activity against cloned human 5-hydroxytryptamine 2A receptor using [125I]DOI as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM705326(US20240279226, Example 12)
Affinity DataIC50: 0.0400nMAssay Description:Compounds of the present application bind to the 5-HT2 receptor subtypes in the following assays: Compounds of the invention are tested on 5-HT2A and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231440(N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM676150(US20240166618, Compound 51)
Affinity DataKi:  0.0400nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM139371(eplivanserin)
Affinity DataKi:  0.0460nM ΔG°:  -54.8kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50171676(8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity for 5-hydroxytryptamine 2A receptor expressed in 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50099273(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-2-phenyl-1H-i...)
Affinity DataKi:  0.0600nMAssay Description:Ability to displace [3H]ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM631402(US20230348421, Compound 31)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]ketanserin from human brain cortex 5-HT2A receptor by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50099273(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-2-phenyl-1H-i...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570568(US11440884, Example 29)
Affinity DataKi:  0.0630nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataIC50: 0.0690nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM85034(BW-501C | BW-501 | BW501)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50320375((E)-1-(2-(4-(4-fluorostyryl)phenylsulfonyl)phenyl)...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]- ketanserin from human 5HT2A receptor expressed CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570567(US11440884, Example 28)
Affinity DataKi:  0.0790nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50649142(CHEMBL5618291)
Affinity DataKi:  0.0790nMAssay Description:Displacement of [3H]Ketanserin from recombinant human 5-HT2A receptor extracted from CHO cell membrane incubated for 60 mins by radioligand binding a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50095041(Ethyl-{2-[2-(3-fluoro-phenyl)-1H-indol-3-yl]-ethyl...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]ketanserin from CHO cells expressing human 5-hydroxytryptamine 2A receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231445(N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM119676(US8680119, 15)
Affinity DataIC50: 0.0820nMpH: 7.4Assay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataKi:  0.0830nM ΔG°:  -53.5kJ/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50297306({2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-eth...)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50099255(6-Fluoro-2-(4-fluoro-phenyl)-3-piperidin-3-yl-1H-i...)
Affinity DataKi:  0.0900nMAssay Description:Ability to displace [3H]ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231453(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50099275(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi:  0.0900nMAssay Description:Ability to displace [3H]ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50343274(7-(4-(4-(5,6,7,8-tetrahydronaphthalen-1-yl)piperaz...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50547388(CHEMBL4758966)
Affinity DataKi:  0.0910nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50547385(CHEMBL4745124)
Affinity DataKi:  0.0940nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50271706(N-(2-[3H-OCH3]benzyl)-2-(2-[3H-OCH3]-5-methoxy-4-i...)
Affinity DataKd:  0.0970nMAssay Description:Binding affinity to human 5HT2A receptor expressed in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570517([4-(propan-2-yloxy)phenyl]methyl N-[(4-fluoropheny...)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570524([4-(propan-2-yloxy)phenyl]methyl N-[(4-fluoropheny...)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50231452(N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50014997(DOHx | 1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-ami...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570571(US11440884, Example 32)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570525( [4-(propan-2-yloxy)phenyl]methyl N-[(3R,4S)-3-flu...)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570526([4-(propan-2-yloxy)phenyl]methyl N-[(3S,4R)-3-fluo...)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570574(US11440884, Example 35)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570616(US11440884, Example 67)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM50038677((4-Bromo-benzyl)-[2-(5-methoxy-1H-indol-3-yl)-ethy...)
Affinity DataKi:  0.100nMAssay Description:Affinity against 5-hydroxytryptamine 2A receptor (D) labeled with [125I]DOI.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Jordan

Curated by ChEMBL
LigandPNGBDBM570621(US11440884, Example 71)
Affinity DataKi:  0.100nMAssay Description:R-SAT's were generally performed with 50 ng/well of receptor and 20 ng/well of β-galactosidase plasmid DNA. All receptor constructs used wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

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