Compile Data Set for Download or QSAR
Report error Found 2842 of affinity data for UniProtKB/TrEMBL: P30968
LigandPNGBDBM50369965(Cetrotide | CETRORELIX)
Affinity DataKd:  0.00200nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.0600nMAssay Description:Tested for inhibition of arachidonic acid(AA) release from CHO cells in HumanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50189733(ethyl 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difl...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50189716(ethyl 3-(N-benzyl-N-methylaminomethyl)-4,7-dihydro...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50347996(CHEMBL1800663)
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50122652(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 0.0700nMAssay Description:Tested for inhibition of arachidonic acid(AA) release from CHO cells in HumanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50347986(CHEMBL1800155)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347996(CHEMBL1800663)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347985(CHEMBL1800156)
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347997(CHEMBL1800661)
Affinity DataIC50: 0.0800nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347989(CHEMBL1800668)
Affinity DataIC50: 0.0800nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347984(CHEMBL1800157)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347994(CHEMBL1800666)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347997(CHEMBL1800661)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347989(CHEMBL1800668)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50155363(7-Chloro-2-oxo-4-[2-(4-oxo-azetidin-2-yl)-ethoxy]-...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity towards human gonadotropin releasing hormone receptor expressed in CHO cells was determined by using [125I]-buserelin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50189701(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50189703(N-(4-(7-(2,6-difluorobenzyl)-5-benzoyl-3-((benzyl(...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50122652(1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)ami...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50347995(CHEMBL1800664)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50189704(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50189701(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM230879(US9346822, 41)
Affinity DataIC50: 0.100nMAssay Description:The monkey and human membrane fractions prepared were diluted with the assay buffer to yield a 200 g/ml dilution, each of which was then dispensed at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details
US Patent

LigandPNGBDBM50189730(ethyl 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50409694(CHEMBL2092994)
Affinity DataIC50: 0.100nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50347987(CHEMBL1800153)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM439612(1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...)
Affinity DataIC50: 0.110nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

LigandPNGBDBM50526065(CHEMBL4454362)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]-D-Tyr6-His5-GnRH from recombinant human GnRH receptor expressed in HEK293 cell membrane measured after 16 to 19 hrs by gamma c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM405268(US10344034, Example 14 | 1-(4-(7-(2,6-difluorobenz...)
Affinity DataIC50: 0.110nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

LigandPNGBDBM50347983(CHEMBL1800158)
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50369965(Cetrotide | CETRORELIX)
Affinity DataKd:  0.135nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50085814(dicyclo(4-10/5,5-8)[Ac-D2Nal-DCpa-DPal-Asp-Glu(Gly...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity towards Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50533873(CHEMBL4585638)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533953(CHEMBL4474379)
Affinity DataIC50: 0.160nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533944(CHEMBL4516712)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50347986(CHEMBL1800155)
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50533933(CHEMBL4566719)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50347987(CHEMBL1800153)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50067485(CHEMBL544440 | 3-[(Benzyl-methyl-amino)-methyl]-7-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50189707(3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobe...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50122660(1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difl...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50347988(CHEMBL1800152 | US9346822, 40)
Affinity DataIC50: 0.200nMAssay Description:The monkey and human membrane fractions prepared were diluted with the assay buffer to yield a 200 g/ml dilution, each of which was then dispensed at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details
US Patent

LigandPNGBDBM50122659(N-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difl...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist concentration required to inhibit specific binding of [125I]leuprorelin to human luteinizing releasing hormone receptor in cloned chinese ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
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