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TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.488nMAssay Description:Inhibition of human GCK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  0.800nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  0.800nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human GCK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239045(CHEMBL4083339)
Affinity DataEC50: <0.850nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054107(CHEMBL3319533)
Affinity DataIC50: 1nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  1nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  1nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  1.40nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM249124(US9453038, 1)
Affinity DataEC50:  1.90nMT: 2°CAssay Description:To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  2nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447276(CHEMBL3113985)
Affinity DataIC50: 2nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM249145(US9453038, 23)
Affinity DataEC50:  2.10nMT: 2°CAssay Description:To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239044(CHEMBL4104680)
Affinity DataEC50:  3.40nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM249137(US9453038, 15)
Affinity DataEC50:  3.80nMT: 2°CAssay Description:To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447275(CHEMBL3114185)
Affinity DataIC50: 4nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  4.20nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239048(CHEMBL4067028)
Affinity DataEC50:  4.20nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM249148(US9453038, 26)
Affinity DataEC50:  4.30nMT: 2°CAssay Description:To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239043(CHEMBL4067037)
Affinity DataEC50:  4.80nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054106(CHEMBL3319534)
Affinity DataIC50: 5nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054052(CHEMBL3319549)
Affinity DataIC50: 5nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50008283(CHEMBL3235148)
Affinity DataEC50:  5nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054097(CHEMBL3319540)
Affinity DataIC50: 5nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50053952(CHEMBL3319529)
Affinity DataIC50: 5nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  5.5nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239040(CHEMBL4086771)
Affinity DataEC50:  5.5nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM260385(US9527838, 13)
Affinity DataEC50:  5.70nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089139(CHEMBL3577715)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089180(CHEMBL3577735)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089108(CHEMBL3577727)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089134(CHEMBL3577728)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089135(CHEMBL3577729)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447274(CHEMBL3114183)
Affinity DataIC50: 6nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447273(CHEMBL3114186)
Affinity DataIC50: 6nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054057(CHEMBL3319544)
Affinity DataIC50: 6nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM260423(US9527838, 51)
Affinity DataEC50:  6.20nMAssay Description:Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50089181(CHEMBL3577736)
Affinity DataEC50:  7nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose as substrate by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447272(CHEMBL3113980)
Affinity DataIC50: 7nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054094(CHEMBL3319541)
Affinity DataIC50: 7nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054063(CHEMBL3319542)
Affinity DataIC50: 7nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM260373(US9527838, 1)
Affinity DataEC50:  7.5nMAssay Description:Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM260425(US9527838, 53)
Affinity DataEC50:  7.60nMAssay Description:Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50008306(CHEMBL3235155)
Affinity DataEC50:  8nMAssay Description:Activation of recombinant human pancreatic glucokinase using 10 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM260396(US9527838, 24)
Affinity DataEC50:  8nMAssay Description:Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50054059(CHEMBL3319543)
Affinity DataIC50: 8nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50239044(CHEMBL4104680)
Affinity DataEC50:  8.20nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM249157(US9453038, 35)
Affinity DataEC50:  8.90nMT: 2°CAssay Description:To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM260385(US9527838, 13)
Affinity DataEC50:  9nMAssay Description:Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E. coli, and purified on ANTIFLAG M2 AFFINITY GEL (Sigma). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50447271(CHEMBL3114187)
Affinity DataIC50: 9nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
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