Compile Data Set for Download or QSAR
Report error Found 233 of affinity data for UniProtKB/TrEMBL: P36639
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511450BDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511450BDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511450BDBM50511450(CHEMBL4436749)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511431BDBM50511431(CHEMBL4468099)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511430BDBM50511430(CHEMBL4455353)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511453BDBM50511453(CHEMBL4451394)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511452BDBM50511452(CHEMBL4570266)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548115BDBM50548115(CHEMBL4778773)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255621BDBM50255621(CHEMBL4070624)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255603BDBM50255603(CHEMBL4083992)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255598BDBM50255598(CHEMBL4064004)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255566BDBM50255566(CHEMBL4094252)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255568BDBM50255568(CHEMBL4091768)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255581BDBM50255581(CHEMBL4073623)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255624BDBM50255624(CHEMBL4101983)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255622BDBM50255622(CHEMBL4067896)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255582BDBM50255582(CHEMBL4078783)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511454BDBM50511454(CHEMBL4460228)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511432BDBM50511432(CHEMBL4435945)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511466BDBM50511466(CHEMBL4529335)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548110BDBM50548110(CHEMBL4747532)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162074BDBM50162074(CHEMBL3792684)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152144BDBM50152144(CHEMBL3781661)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152144BDBM50152144(CHEMBL3781661)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152127BDBM50152127(CHEMBL3780962)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548110BDBM50548110(CHEMBL4747532)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511448BDBM50511448(CHEMBL4460446)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162075BDBM50162075(CHEMBL3794167)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511428BDBM50511428(CHEMBL4435983)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152129BDBM50152129(CHEMBL3780596)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152130BDBM50152130(CHEMBL3780613)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548109BDBM50548109(CHEMBL4783492)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162074BDBM50162074(CHEMBL3792684)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162074BDBM50162074(CHEMBL3792684)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548117BDBM50548117(CHEMBL4776026)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162075BDBM50162075(CHEMBL3794167)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50162075BDBM50162075(CHEMBL3794167)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152145BDBM50152145(CHEMBL3780032)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511463BDBM50511463(CHEMBL4577002)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511457BDBM50511457(CHEMBL4537820)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152125BDBM50152125(CHEMBL3781316)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152125BDBM50152125(CHEMBL3781316)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152125BDBM50152125(CHEMBL3781316)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using dGTP as substrate measured after 30 mins by mala...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511439BDBM50511439(CHEMBL4565830)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548124BDBM50548124(CHEMBL4784602)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255583BDBM50255583(CHEMBL4096813)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511458BDBM50511458(CHEMBL4534555)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152125BDBM50152125(CHEMBL3781316)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50548109BDBM50548109(CHEMBL4783492)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255623BDBM50255623(CHEMBL4072758)
Affinity DataIC50: 1nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
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