Compile Data Set for Download or QSAR
Report error Found 336 for UniProtKB: Q08828
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144001BDBM50144001(3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...)
Affinity DataKi:  14nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144020BDBM50144020(3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...)
Affinity DataKi:  17nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144015BDBM50144015(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...)
Affinity DataKi:  20nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052137BDBM50052137(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144008BDBM50144008(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Affinity DataKi:  29nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010274BDBM50010274(CHEMBL328561 | Acetic acid (3R,4aR,5S,6S,6aS,10S,1...)
Affinity DataIC50: 31nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052124BDBM50052124(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 32nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144002BDBM50144002(3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...)
Affinity DataKi:  33nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052123BDBM50052123(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 36nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052141BDBM50052141(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-[2-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010261BDBM50010261(colforsinum | cid_47936 | colforsina | colforsine ...)
Affinity DataIC50: 41nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052142BDBM50052142((2-Hydroxy-ethyl)-carbamic acid (3R,4aR,5S,6S,6aS,...)
Affinity DataIC50: 43nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052136BDBM50052136(3-((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-Acetoxy-10,1...)
Affinity DataIC50: 44nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052143BDBM50052143([2-(4-Amino-phenyl)-ethyl]-carbamic acid (3R,4aR,5...)
Affinity DataIC50: 64nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052129BDBM50052129(Phenethyl-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR...)
Affinity DataIC50: 65nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144008BDBM50144008(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Affinity DataKi:  69nMAssay Description:In vitro inhibitory activity against glucagon induced monkey adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664332BDBM50664332(CHEMBL6169928)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664323BDBM50664323(CHEMBL6166043)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664324BDBM50664324(CHEMBL6150287)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50004822BDBM50004822(CHEMBL24077 | SKF 38393 (+) | SK-383933 | R(+)SKF ...)
Affinity DataEC50:  71nMAssay Description:Compound was tested for the adenylate cyclase stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052132BDBM50052132(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(2-...)
Affinity DataIC50: 73nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052127BDBM50052127(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 76nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052149BDBM50052149(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-all...)
Affinity DataIC50: 76nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664364BDBM50664364(CHEMBL6133492)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052140BDBM50052140(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 82nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052131BDBM50052131(Propyl-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10...)
Affinity DataIC50: 89nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010269BDBM50010269(CHEMBL327672 | [2-(4-Hydroxy-phenyl)-ethyl]-carbam...)
Affinity DataIC50: 95nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664319BDBM50664319(CHEMBL6164072)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664345BDBM50664345(CHEMBL6164876)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664346BDBM50664346(CHEMBL6165758)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144003BDBM50144003(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-trifluoromethox...)
Affinity DataKi:  110nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664356BDBM50664356(CHEMBL6162018)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052116BDBM50052116(Isobutyl-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,...)
Affinity DataIC50: 112nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052146BDBM50052146((2-Pyridin-2-yl-ethyl)-carbamic acid (3R,4aR,5S,6S...)
Affinity DataIC50: 117nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052133BDBM50052133(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-cyc...)
Affinity DataIC50: 117nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664377BDBM50664377(CHEMBL6167528)
Affinity DataIC50: 120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052148BDBM50052148((2-Piperidin-1-yl-ethyl)-carbamic acid (3R,4aR,5S,...)
Affinity DataIC50: 123nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010268BDBM50010268(CHEMBL91909 | (2-Amino-ethyl)-carbamic acid (3R,4a...)
Affinity DataIC50: 128nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664370BDBM50664370(CHEMBL6162089)
Affinity DataIC50: 140nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052150BDBM50052150(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-10,10...)
Affinity DataIC50: 142nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052130BDBM50052130((2-Pyridin-2-yl-ethyl)-carbamic acid (3R,4aR,5S,6S...)
Affinity DataIC50: 143nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144016BDBM50144016(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Affinity DataKi:  144nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052139BDBM50052139(Allyl-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10b...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052120BDBM50052120(Isobutyl-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052145BDBM50052145([2-(4-Amino-phenyl)-ethyl]-carbamic acid (3R,4aR,5...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052126BDBM50052126((2-Piperidin-1-yl-ethyl)-carbamic acid (3R,4aR,5S,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664348BDBM50664348(CHEMBL6172038)
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052133BDBM50052133(Acetic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-cyc...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052135BDBM50052135((2-Dimethylamino-ethyl)-carbamic acid (3R,4aR,5S,6...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Human)
Food and Drug Administration

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50052111BDBM50052111((2-Methoxy-ethyl)-carbamic acid (3R,4aR,5S,6S,6aS,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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