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TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248645(CHEMBL4061525)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350259(US10208056, Compound 86)
Affinity DataIC50: 0.480nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248633(CHEMBL4083552)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248656(CHEMBL4086487)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350253(US10208056, Compound 80)
Affinity DataIC50: 0.770nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248635(CHEMBL4070408)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350249(US10208056, Compound 76)
Affinity DataIC50: 0.827nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248611(CHEMBL4060856)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248614(CHEMBL4066819)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248612(CHEMBL4076395)
Affinity DataIC50: 1nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350211(US10208056, Compound 43)
Affinity DataIC50: 1.09nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248640(CHEMBL4074204)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248686(CHEMBL4071040)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692548(US20240270735, Compound A110)
Affinity DataIC50: 1.30nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248638(CHEMBL4062244)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248690(CHEMBL4082469)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350202(US10208056, Compound 34)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350256(US10208056, Compound 83)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350220(US10208056, Compound 52)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350263(US10208056, Compound 90)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350190(US10208056, Compound 22)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350183(US10208056, Compound 15)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350239(US10208056, Compound 66)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350240(US10208056, Compound 67)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM350262(US10208056, Compound 89)
Affinity DataIC50: 1.41nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.5nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.5nMAssay Description:Binding constant for CDK11 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.5nMAssay Description:Binding constant for CDK11 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50529873(CHEMBL4552616)
Affinity DataIC50: 1.90nMAssay Description:Displacement of Kinase tracer 236 from GST-fused CDK19/cyclin C (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248615(CHEMBL4077627)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50529873(CHEMBL4552616)
Affinity DataIC50: 1.90nMAssay Description:Displacement of Kinase tracer 236 from GST-fused CDK19/cyclin C (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50573483(CHEMBL4877883 | US12410194, Compound 020)
Affinity DataIC50: 2nMAssay Description:Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50573487(CHEMBL4850566)
Affinity DataIC50: 2nMAssay Description:Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692571(US20240270735, Compound A146)
Affinity DataIC50: 2.20nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248687(CHEMBL4090775)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692495(US20240270735, Compound A59)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692501(US20240270735, Compound A125)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692502(US20240270735, Compound A63)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692560(US20240270735, Compound A133)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692499(US20240270735, Compound A62)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692500(US20240270735, Compound A124)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692556(US20240270735, Compound A118)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692580(US20240270735, Compound A156)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692553(US20240270735, Compound A115)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692491(US20240270735, Compound A58)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of CDK19 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692547(US20240270735, Compound A109)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692572(US20240270735, Compound A147)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM692513(US20240270735, Compound B89)
Affinity DataIC50: 2.5nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
US Patent

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