Compile Data Set for Download or QSAR
Report error Found 343 for UniProtKB: Q9ERZ8
LigandPNGBDBM50222640(CHEMBL415543)
Affinity DataIC50: 0.320nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50222640(CHEMBL415543)
Affinity DataIC50: 0.320nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222695(CHEMBL155433)
Affinity DataIC50: 0.460nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222637(CHEMBL154743)
Affinity DataIC50: 0.5nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222696(CHEMBL156041)
Affinity DataIC50: 0.550nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222635(CHEMBL267205)
Affinity DataIC50: 0.720nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50522021(CHEMBL4465116)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50222647(CHEMBL154990)
Affinity DataIC50: 0.950nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222649(CHEMBL155730)
Affinity DataIC50: 0.950nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521996(CHEMBL4459940)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50222641(CHEMBL157962)
Affinity DataIC50: 1.20nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232815(CHEMBL4104743)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50232797(CHEMBL4073922)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of hypotonicity-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50222638(CHEMBL422702)
Affinity DataIC50: 2.40nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232790(CHEMBL4084542)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232813(CHEMBL4097859)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232800(CHEMBL4103166)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232804(CHEMBL4087716)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232796(CHEMBL4094483)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50222644(CHEMBL434295)
Affinity DataIC50: 2.5nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222648(CHEMBL156693)
Affinity DataIC50: 3nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232803(CHEMBL4068023)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50222639(CHEMBL356682)
Affinity DataIC50: 3.20nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232799(CHEMBL4078886)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50525957(CHEMBL4461515)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at rat recombinant TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50232798(CHEMBL4095413)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232809(CHEMBL4065154)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50256209(CHEMBL4101768)
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50222646(CHEMBL157917)
Affinity DataIC50: 5.10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50502650(CHEMBL4549613)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50232805(CHEMBL4069979)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50222694(CHEMBL158189)
Affinity DataIC50: 6.10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232791(CHEMBL4062863)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50232802(CHEMBL4105593)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50256228(CHEMBL4099293)
Affinity DataIC50: 8.20nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50222691(CHEMBL156927)
Affinity DataIC50: 9.30nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222690(CHEMBL345157)
Affinity DataIC50: 10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222645(CHEMBL157918)
Affinity DataIC50: 11nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50222693(CHEMBL157579)
Affinity DataIC50: 12nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2018
Entry Details Article
PubMed
LigandPNGBDBM50232811(CHEMBL4105323)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50192804(CHEMBL3933401)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50224228(CHEMBL46233)
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory concentration was determined against [45Ca2+]- influx in rat DRG neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details Article
PubMed
LigandPNGBDBM50232793(CHEMBL4100026)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
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