Compile Data Set for Download or QSAR
Report error Found 164 for UniProtKB: Q9QUK6
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630277(CHEMBL507938)
Affinity DataEC50:  0.00500nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630277(CHEMBL507938)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630283(CHEMBL5423611)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630282(CHEMBL5407887)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630280(CHEMBL5433813)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630283(CHEMBL5423611)
Affinity DataEC50:  0.190nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630278(CHEMBL5432710)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630279(CHEMBL5422378)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630278(CHEMBL5432710)
Affinity DataEC50:  0.370nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630276(CHEMBL5428754)
Affinity DataEC50:  0.430nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630276(CHEMBL5428754)
Affinity DataEC50:  0.480nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630275(CHEMBL5417929)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630280(CHEMBL5433813)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630282(CHEMBL5407887)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of IL-6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630275(CHEMBL5417929)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of NO productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of TNF-alpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630279(CHEMBL5422378)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630274(CHEMBL5434803)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of TLR4 in LPS/INFgamma stimulated mouse peritoneal macrophages assessed as inhibition of IL1-beta after 20 hrs by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630274(CHEMBL5434803)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50029089(CHEMBL3360821)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391678(CHEMBL1569494)
Affinity DataIC50: 310nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391682(CHEMBL2148167)
Affinity DataIC50: 330nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391691(CHEMBL2148182)
Affinity DataIC50: 410nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391678(CHEMBL1569494)
Affinity DataIC50: 420nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of IL1-beta production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391683(CHEMBL2148176)
Affinity DataIC50: 420nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391690(CHEMBL2148181)
Affinity DataIC50: 520nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50029088(CHEMBL3360820)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391674(CHEMBL2148171)
Affinity DataIC50: 710nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLymphocyte antigen 96/Toll-like receptor 4(Mouse)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50501802(CHEMBL4544533)
Affinity DataIC50: 730nMAssay Description:Inhibition of MD2-TLR4 protein-protein interaction in ICR mouse peritoneal macrophages assessed as reduction in LPS-induced IL-6 production preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391687(CHEMBL2148169)
Affinity DataIC50: 740nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50029087(CHEMBL3360819)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391679(CHEMBL2148166)
Affinity DataIC50: 820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391686(CHEMBL2148168)
Affinity DataIC50: 820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50250439(CHEMBL4068003)
Affinity DataEC50:  820nMAssay Description:Agonist activity at mouse TLR4 expressed in HEK293 blue cells assessed as induction of NF-kappaB activation-mediated SEAP production after 20 to 24 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391692(CHEMBL2148170)
Affinity DataIC50: 820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391693(CHEMBL2148177)
Affinity DataIC50: 820nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391684(CHEMBL2148183)
Affinity DataIC50: 930nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50640852(CHEMBL5542409)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at TLR4 in mouse BV-2 cells assessed as inhibition of LPS-induced NO overproduction incubated for 24 hrs by 2,3-diaminonaphthalen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50089805(CHEMBL3577590)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391676(CHEMBL2148174)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50640850(CHEMBL5583715)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at TLR4 in mouse BV-2 cells assessed as inhibition of LPS-induced NO overproduction incubated for 24 hrs by 2,3-diaminonaphthalen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391675(CHEMBL2148173)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50089806(CHEMBL3577591)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50089824(CHEMBL3577592)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against TLR4 in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by 2,3-diamino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50391673(CHEMBL2148184)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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