24 articles for thisTarget
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Synthesis and bioactivity ofß-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Universiteit Gent
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR).
University of Strasburg
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.
Heinrich Heine Universit£T
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
University of Groningen
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.
George Washington University
IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
Lehrstuhl FÜR Biochemie
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.
Uppsala University
AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase.
Philipps University
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
University of Strasburg
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.
Baylor College of Medicine
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis.
Uppsala University
Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation.
Oregon State University
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
Uppsala University
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
Baylor College of Medicine
Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs.
George Washington University
Non-hydroxamate inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): A critical review and future perspective.
Birla Institute of Technology and Science-Pilani
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.
Ghent University
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
Ghent University
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Heinrich Heine University D£Sseldorf
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
University of Illinois At Urbana - Champaign
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
University of Pennsylvania
Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics.
Mayo Foundation
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Gsk