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Report error Found 12 of affinity data for UniProtKB/TrEMBL: P0C6U2
TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 50099587BDBM50099587(US8815934, No. 107 | CHEMBL44426 | US8815934, No. ...)
Affinity DataEC50:  110nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 429505BDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  140nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803822BDBM803822(US20260124192, Compound MCAA-06)
Affinity DataEC50:  290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803819BDBM803819(US20260124192, Compound MCAA-01)
Affinity DataEC50:  1.88E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803825BDBM803825(US20260124192, Compound MCAA-11)
Affinity DataEC50:  2.74E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803820BDBM803820(US20260124192, Compound MCAA-02)
Affinity DataEC50:  2.78E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803824BDBM803824(US20260124192, Compound MCAA-10)
Affinity DataEC50:  2.85E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803826BDBM803826(US20260124192, Compound MCAA-12)
Affinity DataEC50:  2.94E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803827BDBM803827(US20260124192, Compound MCAA-13)
Affinity DataEC50:  2.96E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803821BDBM803821(US20260124192, Compound MCAA-05)
Affinity DataEC50: >5.00E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803828BDBM803828(US20260124192, Compound MCAA-15)
Affinity DataEC50: >5.00E+3nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(HCoV-229E)
Model Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 803823BDBM803823(US20260124192, Compound MCAA-08)
Affinity DataEC50:  3.30E+4nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent