Compile Data Set for Download or QSAR
Report error Found 4 of affinity data for UniProtKB/TrEMBL: Q03526
TargetTyrosine-protein kinase ITK/TSK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(N-(5-(5-(1-acetylpiperazine-4-carbonyl)-4-methoxy-...)
Affinity DataIC50: 72nMAssay Description:Inhibition of Itk in mouse EL4 cells assessed as inhibition of IL-2 secretion incubated for 16 hrs in presence of anti-CD3 antibody G19-4 by ELISA an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ITK/TSK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(N-(5-(3-(1-acetylpiperazine-4-carbonyl)-4,5-dimeth...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Itk in mouse EL4 cells assessed as inhibition of IL-2 secretion incubated for 16 hrs in presence of anti-CD3 antibody G19-4 by ELISA an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(N-(5-(5-(1-acetylpiperazine-4-carbonyl)-4-methoxy-...)
Affinity DataIC50: 380nMAssay Description:Inhibition of Itk in mouse Splenocyte cells assessed as inhibition of IL-2 secretion incubated for 16 hrs in presence of anti-CD3 antibody G19-4 by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ITK/TSK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182833(N-(5-(3-(1-acetylpiperazine-4-carbonyl)-4,5-dimeth...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of Itk in mouse Splenocyte cells assessed as inhibition of IL-2 secretion incubated for 16 hrs in presence of anti-CD3 antibody G19-4 by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed