BDBM50241242 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside::7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one::7-Glucoluteolin::7-Glucosylluteolin::CHEMBL233929::Cinaroside::Cynaroside::Luteolin 7-O-β-D-glucoside (13)::Luteolin 7-O-glucopyranoside::Luteolin 7-O-glucoside::Luteolin 7-glucoside::Luteolin 7-monoglucoside::Luteolin-7-glucoside::Luteoloside::cid_5280637::luteolin 7-O-beta-D-glucoside

SMILES OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=PEFNSGRTCBGNAN-QNDFHXLGSA-N

Data  14 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50241242   

TargetSerine/threonine-protein kinase 33(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataEC50:  1.29E+4nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of Plasmodium falciparum FablMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls University Of Tuebingen

LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  2.45E+3nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University Of Daegu

LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  7.16E+4nMpH: 6.0Assay Description:PTP1B activity was measured by adding 2mM p-NPP and PTP1B in a 50 mM citrate buffer (pH 6.0, 0.1 M NaCl, 1 mMEDTA, and 1 mM dithiothreitol), with or ...More data for this Ligand-Target Pair
In DepthDetails
TargetAcetylcholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  7.47E+4nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
In DepthDetails
TargetInterleukin-2(Homo sapiens (Human))
The Second People'S Hospital Of Fujian Provinc

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataKd:  20nMAssay Description:Binding affinity to IL-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People'S Hospital Of Fujian Provinc

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataKd:  790nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Freie Universitaet Berlin

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  5.12E+4nMAssay Description:Inhibition of influenza A virus (A/Perth/16/2009(H3N2)) neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (strain A/USSR/90/1977 H1N1))
Freie Universitaet Berlin

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  6.66E+4nMAssay Description:Inhibition of influenza A virus (A/California/07/2009(H1N1)) pdm09 neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
University Of Calabria

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition of ACE in rabbit lung assessed as decrease in dansylglycine concentration after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  7.59E+4nMAssay Description:Inhibition of cow milk xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  4.74E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  5.22E+4nMAssay Description:Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  5.86E+4nMAssay Description:Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  4.68E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  4.73E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls University Of Tuebingen

LigandPNGBDBM50241242(2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...)
Affinity DataIC50:  8.71E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed