BDBM50378582 APIGETRIN::Apigenin 7-O-β-D-glucoside (8)::NSC-407303

SMILES c1cc(ccc1C2=CC(=O)c3c(cc(cc3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O

InChI Key InChIKey=KMOUJOKENFFTPU-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50378582   

TargetTumor necrosis factor(Human)
The Second People'S Hospital of Fujian Provinc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSialidase(Clostridium perfringens)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 3.93E+4nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTyrosinase(Human)
Hiroshima University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Catholic University of Daegu

LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2017
Entry Details

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Catholic University of Daegu

LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 1.00E+5nMpH: 6.0Assay Description:PTP1B activity was measured by adding 2mM p-NPP and PTP1B in a 50 mM citrate buffer (pH 6.0, 0.1 M NaCl, 1 mMEDTA, and 1 mM dithiothreitol), with or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2017
Entry Details

TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378582BDBM50378582(NSC-407303 | APIGETRIN | Apigenin 7-O-β-D-glu...)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed