BDBM50367209 BESTATIN HYDROCHLORIDE::Ubenimex

SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O

InChI Key InChIKey=VGGGPCQERPFHOB-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50367209   

TargetCytosol aminopeptidase(Human)TBA
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant Leucine aminopeptidase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 200nMAssay Description:Inhibition of full length human recombinant Leukotriene A-4 hydrolase expressed in baculovirus infected Insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAminopeptidase N(Human)TBA
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 800nMAssay Description:Inhibition of Aminopeptidase N (unknown origin) using Ala-AMC as substrate incubated for 30 mins by SpectraMax microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAminopeptidase N(Human)TBA
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of FLAG-tagged human recombinant Aminopeptidase NMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 3.03E+3nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human N-terminal His-tagged Puromycin-sensitive aminopeptidase extracted from Escherichia coli BL21 STAR (DE3) using alanine-4-methoxy-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataKi:  4.10E+3nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and Ki* was reported which is obtained by the equatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataKi:  4.10E+3nMAssay Description:Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataKi:  7.00E+3nMAssay Description:Effect of inhibitor structure on the slow binding inhibition of aminopeptidase M was determined and the Ki was reported which is = k2/k1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of C-terminal Hexa-histidine-tagged human recombinant ERAP1 expressed in Sf9 cells using L-AMC as substrate incubated for 15 mins by Micha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCytosol aminopeptidase(Human)TBA
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataKi:  2.00E+4nMAssay Description:Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50367209(Ubenimex | BESTATIN HYDROCHLORIDE)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal Hexa-histidine-tagged human recombinant ERAP2 expressed in Sf9 cells using R-AMC as substrate incubated for 15 mins by Micha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed