BDBM22985 Aralen::CHEMBL76::CHLOROQUINE PHOSPHATE::Chlorochin::Chloroquine::Chloroquine, 17::med.21724, Compound 8::{4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
SMILES CCN(CC)CCC[C@@H](C)Nc1ccnc2c1ccc(c2)Cl
InChI Key InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 22985
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activityMore data for this Ligand-Target Pair
TargetFalcipain 2(malaria parasite P. falciparum)
Delhi Institute of Pharmaceutical Sciences and Research
Curated by ChEMBL
Delhi Institute of Pharmaceutical Sciences and Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of falcipain-2 in chloroquine sensitive Plasmodium falciparum MRC-02 schizont stage infected in human erythrocytes assessed as reduction i...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine liver DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of bovine liver DHFR incubated for 12 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate incubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataEC50: 68nMpH: 7.5 T: 2°CAssay Description:This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...More data for this Ligand-Target Pair
TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
University of Lille
Curated by ChEMBL
University of Lille
Curated by ChEMBL
Affinity DataIC50: 76.5nMAssay Description:Inhibitory activity against beta-hematin formationMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 79nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
TargetFalcipain-2(malaria parasite P. falciparum)
Delhi Institute of Pharmaceutical Sciences and Research
Curated by ChEMBL
Delhi Institute of Pharmaceutical Sciences and Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in ...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of mTOR (unknown origin) activationMore data for this Ligand-Target Pair
TargetHistidine-rich protein PFHRP-II(malaria parasite P. falciparum)
University of Lille
Curated by ChEMBL
University of Lille
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of beta-hematin polymerizationMore data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...More data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
University of Manchester and Manchester Cancer Research Center
Curated by ChEMBL
University of Manchester and Manchester Cancer Research Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant NQO2More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 2.10E+3nMpH: 7.4Assay Description:Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human cloned ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 3.16E+3nMAssay Description:hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 3.31E+3nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.10E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataKi: 4.37E+3nMAssay Description:Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 4.68E+3nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataKd: 4.70E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.47E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 5.75E+3nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataEC50: 6.27E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 6.50E+3nMAssay Description:Antagonist activity at CXCR4 receptor in human MIA PaCa-2 cells assessed as reduction in forskolin-stimulated inhibition of cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 6.53E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 2...More data for this Ligand-Target Pair
Affinity DataIC50: 7.28E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.28E+3nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
Affinity DataEC50: 7.35E+3nMAssay Description:SARS-CoV-2 was provided by Korea Centers for Disease Control and Prevention (KCDC) . Vero cells were acquired from the ATCC and maintained in the Dul...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 7.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 9.12E+3nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+4nMAssay Description:Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 2...More data for this Ligand-Target Pair