BDBM50204367 CHEMBL410414::dirlotapide

SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1

InChI Key InChIKey=TUOSYWCFRFNJBS-BHVANESWSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50204367   

TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50:  0.0110nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed