BDBM50296358 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid::1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid::AT-2266::CHEMBL826::CI-919::ENOXACIN::PD-107779::Penetrex::enofloxacin

SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(nc12)N1CCNCC1

InChI Key InChIKey=IDYZIJYBMGIQMJ-UHFFFAOYSA-N

Data  7 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50296358   

TargetV-type proton ATPase subunit B, brain isoform(Homo sapiens (Human))
University Of Florida College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of maltose binding protein-fused human V-ATPase subunit B2 binding to F-actinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRISC-loading complex subunit TARBP2(Homo sapiens)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataKd:  1.26E+4nMAssay Description:Binding affinity to human recombinant TRBP by SPR assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universit£

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50:  1.56E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli)
Universit£

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Escherichia coli DNA gyrase GyrA/GyrBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRISC-loading complex subunit TARBP2(Homo sapiens)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataKd:  94nMAssay Description:Enhancement of His6-tagged TRBP (unknown origin) expressed in Escherichia coli BL21(DE3) binding to 32P-labeled Let7 precursor RNA assessed as TRBP K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296358(1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydr...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed