BDBM50185154 (2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic acid ((S)-1-{(R)-(R)-2-hydroxy-1-[(R)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propylcarbamoyl}-2-methyl-butyl)-amide::(2S,3S)-2-[(2S,3S)-2-(acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(2S,3R)-3-hydroxy-2-[3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylamino]-butyryl}-amide::(S)-2-[(R)-(S)-2-((R)-Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(R)-2-hydroxy-1-[(R)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide::CHEMBL207990::Epoxomicin::epoxomycin

SMILES CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(C)=O)C(=O)NC(=O)[C@@H](NC(CC(C)C)C(=O)[C@@]1(C)CO1)[C@@H](C)O

InChI Key InChIKey=ZWCBKZGIPPDRLY-TXLQCSLMSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50185154   

TargetCathepsin S(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50185154((2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50185154((2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50185154((2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic...)
Affinity DataIC50:  160nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50185154((2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50185154((2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoic...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of chymotrypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed