BDBM50376126 ERASTIN

SMILES CCOc1ccccc1-n1c(nc2ccccc2c1=O)C(C)N1CCN(CC1)C(=O)COc1ccc(Cl)cc1

InChI Key InChIKey=BKQFRNYHFIQEKN-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50376126   

TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  140nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent anion-selective channel protein 2(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataKd:  100nMAssay Description:Binding affinity to human VDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed