BDBM50403688 HAPALOSIN

SMILES CCCCCCC[C@H]1OC(=O)C[C@@H](O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H](OC(=O)[C@H]1C)C(C)C

InChI Key InChIKey=NJNAHFYVTBZQHU-LFFUDGMSSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50403688   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50403688(HAPALOSIN)
Affinity DataIC50:  1.48E+4nMAssay Description:Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycopr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50403688(HAPALOSIN)
Affinity DataIC50:  3.13E+4nMAssay Description:Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50403688(HAPALOSIN)
Affinity DataIC50:  4.80E+3nMAssay Description:Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycopr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50403688(HAPALOSIN)
Affinity DataIC50:  5.80E+3nMAssay Description:Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed