BDBM50370294 Examorelin::HEXARELIN::US9708370, Hexareline

SMILES C[C@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O

InChI Key InChIKey=RVWNMGKSNGWLOL-GIIHNPQRSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50370294   

TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  18nMAssay Description:Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet glycoprotein 4(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  2.08E+3nMAssay Description:Displacement of photoactivatable [125I]-Tyr-Bpa-Ala-Hexarelin from CD36 in Sprague-Dawley rat cardiac membranes incubated for 60 mins by densitometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  15.9nMAssay Description:Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet glycoprotein 4(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of photoactivatable [125I]-Tyr-Bpa-Ala-hexarelin binding to CD36 in Sprague-Dawley rat heart membranes after 60 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor [D538G](Homo sapiens (Human))
Valorisation-Recherche, Limited Partnership

US Patent
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  6.08nMAssay Description:GHS-R1a radioreceptor assay using LLCPK-1 membranes overexpressing GSH-R1a and radioiodinated (1-28) rat ghrelin as tracer.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet glycoprotein 4(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  3.33E+3nMpH: 7.3Assay Description:Competition experiments were performed by incubating 50 μg of LLC-PK1 membranes expressing human GHS-R1a with 15 fmol of 125I-Ghrelin and increa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet glycoprotein 4(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50370294(Examorelin | HEXARELIN | US9708370, Hexareline)
Affinity DataIC50:  2.97E+3nMpH: 7.3Assay Description:Competition experiments were performed by incubating 50 μg of LLC-PK1 membranes expressing human GHS-R1a with 15 fmol of 125I-Ghrelin and increa...More data for this Ligand-Target Pair
In DepthDetails US Patent