BDBM50241341 (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one::3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one::4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one::4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone::6-Deoxy-7,8-dihydro-6-oxomorphine::7,8-Dihydromorphinone::CHEMBL398707::Dihydromorfinon::Dihydromorphinone::Dimorphone::HYDROMORPHONE::Hydromorfona::Hydromorphone Hydrochloride::Idromorfone

SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3CCC4=O)ccc5O

InChI Key InChIKey=WVLOADHCBXTIJK-YNHQPCIGSA-N

Data  3 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50241341   

TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataKi:  0.280nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDelta-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataEC50:  1nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataIC50:  1.38E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50241341((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank