BDBM50019848 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole::4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole::CHEMBL10316::Idazoxan::US8633208, Idazoxan

SMILES C1CN=C(N1)C1COc2ccccc2O1

InChI Key InChIKey=HPMRFMKYPGXPEP-UHFFFAOYSA-N

Data  71 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50019848   

TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.02nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.5nMAssay Description:Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.63nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2020
Entry Details Article

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Guinea pig)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in post-mortem human brain frontal cortex membrane measured after 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details Article
PubMed
TargetNischarin(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 8.30nMAssay Description:Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  9.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  9.77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-clonidine from alpha-1 adrenergic receptor in rat brain homogenates in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]clonidine from alpha-2 adrenergic receptor in rat brain homogenates in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2019
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane, determined using [3H]- yohimbine as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Mouse)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 19nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  19.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A/B(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]2-BFI (1 nM) from imidazoline receptor I-2 in human brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  37.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 54nMAssay Description:Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  261nMAssay Description:Ability to displace [3H]prazosin from alpha-1 adrenergic receptor in rat brain homogenates in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
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