BDBM18140 (2S,3S)-2-amino-3-methylpentanoic acid::Isoleucine::L-[14C]Isoleucine

SMILES CC[C@H](C)[C@H](N)C(O)=O

InChI Key InChIKey=AGPKZVBTJJNPAG-WHFBIAKZSA-N

Data  1 KI  2 IC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18140   

TargetProton-coupled amino acid transporter 1(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataKi:  3.70E+7nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataIC50:  1.40E+5nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed