BDBM50206008 6-hydroxy-7-methoxy-2H-chromen-2-one::CHEMBL390320::isoscopoletin

SMILES COc1cc2oc(=O)ccc2cc1O

InChI Key InChIKey=SYTYLPHCLSSCOJ-UHFFFAOYSA-N

Data  7 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50206008   

TargetCarbonic anhydrase 12(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  4.14E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  5.27E+3nMAssay Description:Inhibition of human carbonic anhydrase 13 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  7.37E+3nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  1.59E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi:  2.38E+4nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSorbitol dehydrogenase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50:  5.62E+4nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50:  1.38E+5nMAssay Description:Inhibition of xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of 15LOX in rabbit reticulocytes by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5LOX in human PBMC by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50206008(6-hydroxy-7-methoxy-2H-chromen-2-one | CHEMBL39032...)
Affinity DataIC50:  5.15E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed