BDBM50418610 GW-856553::GW856553X::LOSMAPIMOD::US10550073, Comparative example
SMILES Cc1c(F)cc(cc1-c1ccc(cn1)C(=O)NCC(C)(C)C)C(=O)NC1CC1
InChI Key InChIKey=KKYABQBFGDZVNQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50418610
Affinity DataKi: 7.90nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 7.94nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
Affinity DataKi: 25.1nMAssay Description:Inhibition of GST-tagged p38beta by fluorescence polarization methodMore data for this Ligand-Target Pair
Affinity DataKi: 63.1nMAssay Description:Competitive inhibition of p38alpha catalytic activity using ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: <2.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
Affinity DataIC50: 25.1nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair