BDBM50429758 CHEMBL2336359::N-P-Tolylcinnamamide

SMILES Cc1ccc(NC(=O)\C=C\c2ccccc2)cc1

InChI Key InChIKey=BZTAHBIRTCNRAW-FMIVXFBMSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429758   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429758(CHEMBL2336359 | N-P-Tolylcinnamamide)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50429758(CHEMBL2336359 | N-P-Tolylcinnamamide)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429758(CHEMBL2336359 | N-P-Tolylcinnamamide)
Affinity DataIC50:  4.67E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429758(CHEMBL2336359 | N-P-Tolylcinnamamide)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed