BDBM50325534 CHEMBL267495::nalfurafine
SMILES CN([C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45)C(=O)\C=C\c1ccoc1
InChI Key InChIKey=XGZZHZMWIXFATA-UEZBDDGYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50325534
Affinity DataKi: 0.0190nMAssay Description:Displacement of [3H]DPDPE from human KOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 0.225nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 0.225nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.370nMAssay Description:Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Displacement of [3H]-DAMGO from mu opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse brain membranes without cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 0.582nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrainMore data for this Ligand-Target Pair
Affinity DataKi: 0.582nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrainMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Displacement of [3H]U-69-593 from human DOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse brain membranes without cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataEC50: 5.20nMAssay Description:Inhibition of p38 phosphorylation (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataEC50: 0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
University Of Catania
Curated by ChEMBL
University Of Catania
Curated by ChEMBL
Affinity DataEC50: 0.550nMAssay Description:Inhibition of ERK2 phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at FLAG-tagged human kappa opioid receptor expressed in HEK293 cells assessed as increase in beta-arrestin mediated p38 phosphorylat...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at FLAG-tagged human kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by Wes...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0340nMAssay Description:Agonist activity at kappa opioid receptor in human HEK293 cells after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.720nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0250nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in beta-arrestin mediated p38 phosphorylation...More data for this Ligand-Target Pair