BDBM50321682 CHEMBL1172035::nifeviroc

SMILES O[C@@]1(CN(C[C@@H]1CN1CCC(CC1)N(CC=C)C(=O)OCc1ccc(cc1)[N+]([O-])=O)C(=O)C1CCCC1)c1ccccc1

InChI Key InChIKey=JNSKQYZFEVKYDB-UVMMSNCQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50321682   

TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50321682(CHEMBL1172035 | nifeviroc)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mus musculus)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50321682(CHEMBL1172035 | nifeviroc)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50321682(CHEMBL1172035 | nifeviroc)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced calcium elevationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50321682(CHEMBL1172035 | nifeviroc)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed