BDBM50331515 CHEMBL1708::PAROXETINE::Paroxetine hydrochloride::Paroxetine.HCl::Paxil::Paxil cr
SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
InChI Key InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50331515
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of New Orleans
Curated by ChEMBL
University Of New Orleans
Curated by ChEMBL
Affinity DataKi: 0.0500nMAssay Description:Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.0800nMAssay Description:Displacement of [3H]paroxetine from SERT in human platelet membraneMore data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter in Sprague-Dawley rat frontal cortex after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of New Orleans
Curated by ChEMBL
University Of New Orleans
Curated by ChEMBL
Affinity DataKi: 98nMAssay Description:Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST tagged PKCalpha expressed in Baculovirus infected Sf9 insect cells using KRREILSRRPSYR as ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK1 (535 residues) assessed as decrease in phosphorylation of tubulin preincubated for 30 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK5 (561 residues) assessed as decrease in phosphorylation of tubulin preincubated for 30 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK5 (561 residues) assessed as decrease in phosphorylation of light-activated bovine rod outer ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of C-terminal hexahistidine tagged bovine GRK1 (535 residues) assessed as decrease in phosphorylation of light-activated bovine rod outer ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.89E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.98E+5nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 960nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair