BDBM50012780 (3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl-methanone::CHEMBL8846::Prifelone

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(=O)c1cccs1

InChI Key InChIKey=WAAVMZLJRXYRMA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50012780   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780((3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human neutrophil 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780((3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human platelet Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780((3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory concentration against arachidonate 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012780((3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl...)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed