BDBM50324671 CHEMBL1221984::Purmorphamine

SMILES C1CCC(CC1)n1cnc2c(Nc3ccc(cc3)N3CCOCC3)nc(Oc3cccc4ccccc34)nc12

InChI Key InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50324671   

TargetSmoothened homolog(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50324671(CHEMBL1221984 | Purmorphamine)
Affinity DataEC50:  800nMAssay Description:Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(CHEMBL1221984 | Purmorphamine)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(CHEMBL1221984 | Purmorphamine)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed