BDBM50324671 CHEMBL1221984::Purmorphamine
SMILES C1CCC(CC1)n1cnc2c(Nc3ccc(cc3)N3CCOCC3)nc(Oc3cccc4ccccc34)nc12
InChI Key InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50324671
Affinity DataEC50: 800nMAssay Description:Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase a...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Stanford University School Of Medicine
Curated by ChEMBL
Stanford University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopyMore data for this Ligand-Target Pair
TargetSonic hedgehog protein(Mus musculus (Mouse))
Stanford University School Of Medicine
Curated by ChEMBL
Stanford University School Of Medicine
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair