BDBM50036935 8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine::CHEMBL91397::Rupatadine

SMILES [#6]-c1cncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)c1

InChI Key InChIKey=WUZYKBABMWJHDL-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50036935   

TargetHistamine H1 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50036935(8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piper...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]mepyramine from N-terminal HA-tagged H1R (unknown origin) expressed in HEK293T cells measured after 4 hrs by microbeta scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50036935(8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piper...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent neutral amino acid transporter B(0)AT2(Homo sapiens (Human))
Max Planck Institute Of Psychiatry

Curated by ChEMBL
LigandPNGBDBM50036935(8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piper...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50036935(8-Chloro-11-[1-(5-methyl-pyridin-3-ylmethyl)-piper...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory concentration against platelet activating factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed