BDBM50309827 CHEMBL597845::Salermide
SMILES CC(C(=O)Nc1cccc(c1)\N=C\c1c(O)ccc2ccccc12)c1ccccc1
InChI Key InChIKey=HQSSEGBEYORUBY-WPWMEQJKSA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50309827
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of His-tagged recombinant human SIRT1 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of recombinant human full length SIRT2 using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.28E+4nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of SIRT1More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 7.62E+4nMAssay Description:Inhibition of recombinant human His-tagged SIRT1 assessed as inhibition of deacetylase activity measured after 60 mins by Fluor de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 3.75E+4nMAssay Description:Inhibition of recombinant human GST or His6-tagged SIRT1 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of recombinant human His6-tagged SIRT2 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 12 mins in presence of bet...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University
Curated by ChEMBL
Jiangsu University
Curated by ChEMBL
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of recombinant human His6-tagged SIRT3 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence of bet...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluores...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human GST-tagged SIRT1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluoresc...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human SIRT2 expressed in Escherichia coli using Gln-Pro-Lys-Lys(Ac) as substrate after 1 hr by Fluor de Lys fluorescence based assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibition of human N-terminal GST-tagged SIRT1 expressed in Escherichia coli using Arg-His- Lys-Lys(Ac) as substrate after 1 hr by Fluor de Lys fluo...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of recombinant human N-tagged GST-SIRT1 fusion protein using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetyl...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of His-tagged recombinant human SIRT2 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair