BDBM50043841 (E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid::CHEMBL277689::Samixogrel

SMILES OC(=O)CCC\C=C(/c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1

InChI Key InChIKey=LGHLGTHRJNIRCA-ZXKDJJQISA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043841   

TargetThromboxane A2 receptor(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  19nMAssay Description:Displacement of the high affinity radiolabeled ligand [3H]- SQ-29,548 from the PGH-2/TXA-2 receptor in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  4nMAssay Description:Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  4nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50043841((E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]...)
Affinity DataIC50:  19nMAssay Description:In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed