BDBM50218197 (-)-beta-Sitosterol::(24R)-Ethylcholest-5-en-3beta-ol::(24R)-Stigmast-5-en-3beta-ol::(3beta)-Stigmast-5-en-3-ol::22,23-Dihydrostigmasterol::24alpha-Ethylcholesterol::Azuprostat::CHEMBL221542::Cupreol::Nimbosterol::Triastonal::alpha-Dihydrofucosterol::beta-Sitosterin::sitosterol::stigmast-5-en-3beta-ol

SMILES CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C

InChI Key InChIKey=KZJWDPNRJALLNS-VJSFXXLFSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50218197   

TargetProthrombin(Homo sapiens (Human))
Institute Of Medicinal And Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataKi:  267nMAssay Description:Uncompetitive inhibition of human thrombin using T1637 as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50:  2.63E+4nMAssay Description:Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute Of Medicinal And Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of thrombin in human washed platelets assessed as reduction in thrombin-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute Of Medicinal And Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in arachidonic acid-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute Of Medicinal And Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Institute Of Medicinal And Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197((-)-beta-Sitosterol | (24R)-Ethylcholest-5-en-3bet...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in thrombin-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed