BDBM29590 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one::CHEMBL86537::splitomicin
SMILES O=C1CCc2c(O1)ccc1ccccc21
InChI Key InChIKey=ISFPDBUKMJDAJH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 29590
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: >7.50E+4nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: >7.50E+4nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Guiyang Medical University
Curated by ChEMBL
Guiyang Medical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Affinity DataIC50: 9.62E+4nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Affinity DataIC50: 1.13E+5nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Institute Of Psychiatry And Neuroscience Of Paris
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >6.00E+5nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: >7.50E+4nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: >7.50E+4nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
Affinity DataIC50: 7.40E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
Fred Hutchinson Cancer Research Center
Curated by ChEMBL
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of yeast Sir 2 proteinMore data for this Ligand-Target Pair