BDBM50200841 CHEMBL220360::MK-0364::MK-0634::N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl)-2-methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanamide::N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide::TARANABANT::Taranbant
SMILES C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc1ccc(Cl)cc1)c1cccc(c1)C#N
InChI Key InChIKey=QLYKJCMUNUWAGO-GAJHUEQPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50200841
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+3nMAssay Description:Displacement of [3H]WIN55212-2 from human CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.860nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inverse agonist activity at cannabinoid CB1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 285nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human CB1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of cannabinoid CB1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of cannabinoid CB2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.930nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Green Cross
Curated by ChEMBL
Green Cross
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of human ERG at holding potential of -80 mV to +40 mVMore data for this Ligand-Target Pair
Affinity DataIC50: 0.740nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]CP-55940 binding to human recombinant CB1 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Inverse agonist activity at human recombinant CB1 receptor assessed as inhibition of forskolin-induced cAMP production in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of [3H]CP-55940 binding to human recombinant CB2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.302nMAssay Description:Antagonist activity against human recombinant cannabinoid-1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of radiolabeled CP5549 binding to human Cannabinoid receptor 1 expressed in CHO cells by competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair