BDBM50059985 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione::CHEMBL318743::tetrahydrocurcumin

SMILES COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O

InChI Key InChIKey=LBTVHXHERHESKG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059985   

TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50059985(1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-d...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of 3'- processing activity of HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena

Curated by ChEMBL
LigandPNGBDBM50059985(1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-d...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Ramkhamhaeng University

Curated by ChEMBL
LigandPNGBDBM50059985(1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-d...)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50059985(1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-d...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of strand transfer activity of HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Jena

Curated by ChEMBL
LigandPNGBDBM50059985(1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-d...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed