BDBM79181 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride::MLS001146870::SMR000059133::TRIFLUOPERAZINE::TRIFLUOPERAZINE DIHYDROCHLORIDE::Trifluperazine::US11542290, Compound Trifluoperazine::cid_2913535::cid_5566

SMILES CN1CCN(CC1)CCCN2c3ccccc3Sc4c2cc(cc4)C(F)(F)F

InChI Key InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N

Data  71 KI  22 IC50  6 Kd

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 99 hits for monomerid = 79181   

TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  0.532nMAssay Description:Compound was tested for its effect on dopamine saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.960nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  0.960nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKd:  1.04nMAssay Description:Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetDopamine receptor D4(Dog)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  2.63nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetDopamine receptor D4(Dog)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetEmopamil-binding protein-like(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  5.20nMAssay Description:The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  7.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  8nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  14.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  15nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataIC50: 16nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  23.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  29nMAssay Description:The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  32.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  62nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  62.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  63nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  66nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  118nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  135nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  158nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  164nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  182nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  197nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  291nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
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