BDBM488383 2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- 3-yl)-3-chloro-N-(2-hydroxyethyl)-1H-indole-6- carboxamide::US10954241, Example 23::US11548896, Example 23
SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NCCO)c2c(N)ncnc12
InChI Key InChIKey=XKSROQSJCOMSFN-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 488383
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 23.9nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Affinity DataIC50: 14.3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.51E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair