BDBM296590 4-(6-(6-(3-chloro- 4- methoxybenzyl)- 3,6- diazabicyclo[3.1.1] heptan-3- yl)pyridin-3-yl)- 6-(2-hydroxy-2- methylpropoxy) pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 324::US10137124, Example 324::US10172851, Example 324::US10555944, Example 324::US10953005, Example 324
SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cc1Cl
InChI Key InChIKey=MTJCLBKLONOOJT-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 296590
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M](Human)
Array Biopharma
US Patent
Array Biopharma
US Patent
Affinity DataIC50: 15.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
Affinity DataIC50: 11.4nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair